• Users Online: 344
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
Year : 2015  |  Volume : 1  |  Issue : 1  |  Page : 104-113

Pharmacologic pre- and postconditioning for stroke: Basic mechanisms and translational opportunity

1 Department of Radiology and Neurology, Harvard Medical School, Massachusetts General Hospital, Massachusetts, USA
2 Department of Neurosurgery, Cerebrovascular Research Institute, Xuan Wu Hospital, Capital Medical University, Beijing, PR China

Correspondence Address:
Eng H Lo
Massachusetts General Hospital - East Building 149, 13th Street, Charlestown, Massachusetts - 02129
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2394-8108.166380

Rights and Permissions

Beyond reperfusion therapies, there are still no widely effective therapies for ischemic stroke. Although much progress has been made to define the molecular pathways involved, targeted neuroprotective strategies have often failed in clinical trials. An emerging hypothesis suggests that focusing on single targets and mechanisms may not work since ischemic stroke triggers multiple pathways in multiple cell types. In this review, we briefly survey and assess the opportunities that may be afforded by pre- and postconditioning therapies, with particular attention to pharmacologic pre- and postconditioning. Pharmacologic conditioning may be defined as the use of chemical agents either before or shortly after stroke onset to trigger mechanisms of endogenous tolerance that are thought to involve evolutionarily conserved signals that offer broad protection against ischemia. Importantly, many of the pharmacologic agents may also have been previously used in humans, thus providing hope for translating basic mechanisms into clinical applications.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded514    
    Comments [Add]    
    Cited by others 7    

Recommend this journal