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REVIEW ARTICLE
Year : 2015  |  Volume : 1  |  Issue : 1  |  Page : 14-25

Hypothermia for treatment of stroke


Department of Neurology, University of California, San Francisco, and Veterans Affairs Medical Center, San Francisco, California, USA

Correspondence Address:
Midori A Yenari
Neurology 127, VAMC, 4150 Clement St., San Francisco, California - 94121
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2394-8108.164997

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Stroke is a major cause of neurological disability and death in industrialized nations. Therapeutic hypothermia has been shown to protect the brain from ischemia, stroke, and other acute neurological insults at the laboratory level. It has been shown to improve neurological outcome in certain clinical settings including anoxic brain injury due to cardiac arrest and hypoxic-ischemic neonatal encephalopathy. Hypothermia seems to affect multiple aspects of brain physiology and it is likely that multiple mechanisms underlie its protective effect. Understanding the events that occur in the ischemic brain during hypothermia might help lead to an understanding of how to protect the brain against acute injuries.


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