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REVIEW ARTICLE
Year : 2016  |  Volume : 2  |  Issue : 4  |  Page : 153-163

Targeting oxidative stress for the treatment of ischemic stroke: Upstream and downstream therapeutic strategies


Center for Neuroscience Discovery, University of North Texas Health Science Center, Fort Worth, TX 76107, USA

Correspondence Address:
Shaohua Yang
Center for Neuroscience Discovery, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107 2699
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2394-8108.195279

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Excessive oxygen and its chemical derivatives, namely reactive oxygen species (ROS), produce oxidative stress that has been known to lead to cell injury in ischemic stroke. ROS can damage macromolecules such as proteins and lipids and leads to cell autophagy, apoptosis, and necrosis to the cells. This review describes studies on the generation of ROS, its role in the pathogenesis of ischemic stroke, and recent development in therapeutic strategies in reducing oxidative stress after ischemic stroke.


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