| REVIEW ARTICLE |
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| Year : 2017 | Volume
: 3
| Issue : 1 | Page : 1-13 |
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The role of hormesis in the functional performance and protection of neural systems
Edward J Calabrese1, Vittorio Calabrese2, James Giordano3
1 Department of Environmental Health Sciences, School of Public Health and Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA
2 Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Viale Andrea Doria, Catania, Italy
3 Department of Neurology and Biochemistry, Georgetown University Medical Center, Washington, DC 20057, USA
Correspondence Address:
Prof. Edward J Calabrese
School of Public Health and Health Sciences, Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003
USA
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/2394-8108.203257
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This paper addresses how hormesis, a biphasic dose response, can protect and affect performance of neural systems. Particular attention is directed to the potential role of hormesis in mitigating age-related neurodegenerative diseases, genetically based neurological diseases, as well as stroke, traumatic brain injury, seizure, and stress-related conditions. The hormetic dose response is of particular significance since it mediates the magnitude and range of neuroprotective processes. Consideration of hormetic dose-response concepts can also enhance the quality of study designs, including sample size/statistical power strategies, selection of treatment groups, dose spacing, and temporal/repeat measures' features. |
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