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REVIEW ARTICLE
Year : 2017  |  Volume : 3  |  Issue : 2  |  Page : 109-113

Targeting G protein-coupled receptor for pain management


1 Department of Pain Management, Xuanwu Hospital of Capital Medical University; Department of Central Laboratory, Xuanwu Hospital of Capital Medical University, Beijing 100053; Department of Liver Cancer Center, The 302 Hospital, Beijing 100039, China
2 Department of Central Laboratory, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
3 Department of Liver Cancer Center, The 302 Hospital, Beijing 100039, China
4 Department of Immunogenetics Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
5 Department of Pain Management, Xuanwu Hospital of Capital Medical University, Beijing 100053, China

Correspondence Address:
Hongyan Li
Department of Pain Management and Central Laboratory, Xuanwu Hospital of Capital Medical, University, Beijing 100053, China, Liver Cancer Center, The 302 Hospital, Beijing, 100039
China
Jiaxiang Ni
Management, Xuanwu Hospital of Capital Medical, University, Beijing 100053
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/bc.bc_3_17

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Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage. Great progress has been made in understanding the important roles of various G protein-coupled receptors in the regulation of pain transmission. However, many important questions remain uncertain about the precise signal transduction mechanisms. This review focuses opioid receptor and CXC receptor 4 on the effects and mechanisms of pain. Taken together, chemokines and their receptors are potential targets for the development of novel pain management and therapy.


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