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REVIEW ARTICLE
Year : 2019  |  Volume : 5  |  Issue : 1  |  Page : 8-11

Treatment for ischemic stroke: From thrombolysis to thrombectomy and remaining challenges


Department of Neurobiology, Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA, USA

Correspondence Address:
Dr. Tiandong Leng
Department of Neurobiology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310
USA
Dr. Zhi-Gang Xiong
Department of Neurobiology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/bc.bc_36_18

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Stroke is a leading cause of death and long-term disabilities. Despite decades of extensive efforts in search of brain injury mechanisms and therapeutic interventions, pharmacological treatment is limited to the use of thrombolytic agent tissue plasminogen activator, which has limited therapeutic time window and potential side effect of intracranial hemorrhage. Over the past few years, endovascular thrombectomy with stent-retriever devices combined with advanced imaging modalities has transformed the standard of stroke care, offering an opportunity to improve the outcome in selected patients as late as 24 h after the onset of stroke. This mini-review summarizes the advancement in the treatment of ischemic stroke, from thrombolysis to thrombectomy and remaining challenges in the field.


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