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Year : 2019  |  Volume : 5  |  Issue : 2  |  Page : 43-54

Therapeutic hypothermia: Applications in adults with acute ischemic stroke

1 Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
2 Cumming School of Medicine, University of Calgary; Department of Clinical Neurosciences, Hotchkiss Brain Institute, Calgary, AB, Canada
3 Cumming School of Medicine, University of Calgary; Department of Clinical Neurosciences, Hotchkiss Brain Institute; O'Brien Institute for Public Health, Calgary, AB, Canada

Correspondence Address:
Dr. Mohammed A Almekhlafi
1403 29th Street NW, Foothills Medical Centre, Calgary, AB T2N 2T9
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/bc.bc_5_19

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The advent of mechanical thrombectomy and increasing alteplase use have transformed the care of patients with acute ischemic stroke. Patients with major arterial occlusions with poor outcomes now have a chance of returning to independent living in more than half of the cases. However, many patients with these severe strokes suffer major disability despite these therapies. The search is ongoing for agents that can be combined with thrombectomy to achieve better recovery through halting infarct growth and mitigating injury after ischemic stroke. Several studies in animals and humans have demonstrated that therapeutic hypothermia (TH) offers potential to interrupt the ischemic cascade, reduce infarct volume, and improve functional independence. We performed a literature search to look up recent advances in the use of TH surrounding the science, efficacy, and feasibility of inducing TH in modern stroke treatments. While protocols remain controversial, there is a real opportunity to combine TH with the existing therapies to improve outcome in adults with acute ischemic stroke.

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