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REVIEW ARTICLE
Year : 2020  |  Volume : 6  |  Issue : 4  |  Page : 242-247

Mini review (Part I): An experimental concept on exercise and ischemic conditioning in stroke rehabilitation


1 China-America Institute of Neuroscience, Beijing Luhe Hospital, Capital Medical University, Beijing, China
2 Department of Neurosurgery, Wayne State University School of Medicine, Detroit, Michigan, USA
3 China-America Institute of Neuroscience; Department of Neurology, Beijing Luhe Hospital, Capital Medical University, Beijing, China
4 China-America Institute of Neuroscience, Beijing Luhe Hospital, Capital Medical University, Beijing, China; Department of Neurosurgery, Wayne State University School of Medicine, Detroit, Michigan, USA; Department of Neurology, Beijing Luhe Hospital, Capital Medical University, Beijing, China
5 Department of Neurology, Beijing Luhe Hospital, Capital Medical University, Beijing, China; Department of Research and Development Center, John D. Dingell VA Medical Center, Detroit, Michigan, USA

Correspondence Address:
Xiaokun Geng
Department of Neurology, Beijing Luhe Hospital, Capital Medical University, No. 82 Xinhua South Road, Tongzhou District, Beijing 101149

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/bc.bc_63_20

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Stroke remains a leading cause of adult death and disability. Poststroke rehabilitation is vital for reducing the long-term sequelae of brain ischemia. Recently, physical exercise training has been well established as an effective rehabilitation tool, but its efficacy depends on exercise parameters and the patient's capacities, which are often altered following a major cerebrovascular event. Thus, ischemic conditioning as a rehabilitation intervention was considered an “exercise equivalent,” but the investigation is still in its relative infancy. In this mini-review, we discuss the potential for physical exercise or ischemic conditioning and its relation to angiogenesis, neurogenesis, and plasticity in stroke rehabilitation. This allows the readers to understand the context of the research and the application of ischemic conditioning in poststroke rehabilitation.


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