|Year : 2022 | Volume
| Issue : 3 | Page : 163-164
Guillain-Barré syndrome, from the search for Zika to the discovery of asymptomatic campylobacteriosis as a risk factor for neurological syndromes in Veracruz, Mexico
Luis Del Carpio-Orantes
Department of Internal Medicine, General Hospital 71, Instituto Mexicano del Seguro Social, Veracruz, Mexico
|Date of Submission||24-May-2022|
|Date of Decision||26-Jul-2022|
|Date of Acceptance||27-Jul-2022|
|Date of Web Publication||21-Sep-2022|
Luis Del Carpio-Orantes
Department of Internal Medicine, General Hospital 71, Instituto Mexicano del Seguro Social, Veracruz
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Carpio-Orantes LD. Guillain-Barré syndrome, from the search for Zika to the discovery of asymptomatic campylobacteriosis as a risk factor for neurological syndromes in Veracruz, Mexico. Brain Circ 2022;8:163-4
|How to cite this URL:|
Carpio-Orantes LD. Guillain-Barré syndrome, from the search for Zika to the discovery of asymptomatic campylobacteriosis as a risk factor for neurological syndromes in Veracruz, Mexico. Brain Circ [serial online] 2022 [cited 2022 Oct 7];8:163-4. Available from: http://www.braincirculation.org/text.asp?2022/8/3/163/356528
In Mexico, as well as in the rest of America, moments of uncertainty were also experienced when the Chikungunya and Zika viruses arrived from Polynesia in 2014 to 2015, mainly Zika due to its great neurotropic potential, conditioning microcephaly, and Guillain-Barré syndrome. Alerting us from the initial experiences of Oceania and South America and taking time to prepare protocol studies when the viruses arrived in Mexican lands, a situation that took place in 2015.
Guillain–Barré syndrome was modified by the Zika pandemic, mainly the incidence of cases associated with said virus up to 42%, as well as in the neuroconduction pattern that in the pre-Zika era AMAN predominated, while in Zika it was the acute inflammatory demyelinating polyneuropathy (AIDP) pattern, similarly, the less severe character of the disease in terms of recovery and sequelae was more evident in the Zika pandemic era.
By 2016, we had had the first reports of cases in the Mexican southeast, where we studied eight patients with the syndrome, however, none were positive for Zika; for 2017, we studied seven patients of which none reported positivity for Zika, but for dengue and Chikungunya, the presence of Campylobacter being even more noticeable with five patients. In that same year, we made synergy with another hospital in the city and managed to combine 34 patients, of which two were positive for Zika, four for dengue, two for herpes, one for enterovirus, and one for Chikungunya; however, he highlighted again the presence of Campylobacter in 12 cases. The predominance of the AIDP pattern is also highlighted. Following up on the Zika pandemic and in its third year, we had documented a total of 39 cases of Guillain–Barré syndrome, of which only two cases had been associated with Zika, while 13 were with Campylobacter.,,,
Based on this evidence, we decided to look for cases of asymptomatic campylobacteriosis, since most of the previous cases had not presented digestive manifestations. In 2019, a Campylobacter search protocol was carried out in healthy and immunocompetent subjects, 200 volunteers were studied and the presence of the bacteria in a fecal sample was analyzed, six positives were found with a rapid test, and these samples were cultured (campy-BAP medium) finding the development of five cases, four corresponding to Campylobacter jejuni and one to Campylobacter coli, which revealed the neurotropic potential of asymptomatic campylobacteriosis in this population that has previously suffered outbreaks of the syndrome that had not had an adequate epidemiological and in ecological analysis.,
Finally, we consider that in the event of an outbreak of Guillain–Barré syndrome, whether in a pandemic context or not, viruses and bacteria with neurotropic potential must be taken into consideration, always highlighting the search for Campylobacter and even its asymptomatic forms that could at some point disrupt the intestinal microbiota and condition various nosological entities.
| References|| |
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