Brain Circulation

REVIEW ARTICLE
Year
: 2018  |  Volume : 4  |  Issue : 1  |  Page : 1--13

Hypothermia and brain inflammation after cardiac arrest


Pouya Tahsili-Fahadan1, Salia Farrokh2, Romergryko G Geocadin3 
1 Department of Medicine, Virginia Commonwealth University, Falls Church, Virginia; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
2 Department of Pharmacy, Johns Hopkins University School of Medicine, Baltimore, MD, USA
3 Department of Neurology; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Correspondence Address:
Dr. Romergryko G Geocadin
600 N Wolfe Street, Phipps 455, Baltimore, MD 21287
USA

The cessation (ischemia) and restoration (reperfusion) of cerebral blood flow after cardiac arrest (CA) induce inflammatory processes that can result in additional brain injury. Therapeutic hypothermia (TH) has been proven as a brain protective strategy after CA. In this article, the underlying pathophysiology of ischemia-reperfusion brain injury with emphasis on the role of inflammatory mechanisms is reviewed. Potential targets for immunomodulatory treatments and relevant effects of TH are also discussed. Further studies are needed to delineate the complex pathophysiology and interactions among different components of immune response after CA and identify appropriate targets for clinical investigations.


How to cite this article:
Tahsili-Fahadan P, Farrokh S, Geocadin RG. Hypothermia and brain inflammation after cardiac arrest.Brain Circ 2018;4:1-13


How to cite this URL:
Tahsili-Fahadan P, Farrokh S, Geocadin RG. Hypothermia and brain inflammation after cardiac arrest. Brain Circ [serial online] 2018 [cited 2022 May 26 ];4:1-13
Available from: http://www.braincirculation.org/article.asp?issn=2394-8108;year=2018;volume=4;issue=1;spage=1;epage=13;aulast=Tahsili-Fahadan;type=0