Brain Circulation

REVIEW ARTICLE
Year
: 2022  |  Volume : 8  |  Issue : 4  |  Page : 172--179

Neuroprotective approach in acute ischemic stroke: A systematic review of clinical and experimental studies


Fettah Eren1, Sueda Ecem Yilmaz2 
1 Department of Neurology, Faculty of Medicine, Selcuk University, Konya, Turkey
2 Department of Neurology, School of Medicine, Selcuk University, Konya, Turkey

Correspondence Address:
Fettah Eren
Department of Neurology, Faculty of Medicine, Selcuk University, Celal Bayar Street and Number 313, Konya 42700
Turkey

Ischemic stroke is a disease with worldwide economic and social negative effects. It is a serious disease with high disability and mortality. Ionic imbalance, excitotoxicity, oxidative stress, and inflammation are induced during and after ischemic stroke. Cellular dysfunction, apoptosis, and necrosis are activated directly or indirectly mechanisms. The studies about neuroprotection in neurodegenerative diseases have increased in recent years. Data about the mechanisms of progressive molecular improvement in the brain tissue are increasing in acute ischemic stroke. Based on these data, preclinical and clinical studies on new neuroprotective treatments are being designed. An effective neuroprotective strategy can prolong the indication period of recanalization treatments in the acute stage of ischemic stroke. In addition, it can reduce neuronal necrosis and protect the brain against ischemia-related reperfusion injury. The current review has evaluated the recent clinical and experimental studies. The molecular mechanism of each of the neuroprotective strategies is also summarized. This review may help develop future strategies for combination treatment to protect the cerebral tissue from ischemia-reperfusion injury.


How to cite this article:
Eren F, Yilmaz SE. Neuroprotective approach in acute ischemic stroke: A systematic review of clinical and experimental studies.Brain Circ 2022;8:172-179


How to cite this URL:
Eren F, Yilmaz SE. Neuroprotective approach in acute ischemic stroke: A systematic review of clinical and experimental studies. Brain Circ [serial online] 2022 [cited 2023 Jan 31 ];8:172-179
Available from: http://www.braincirculation.org/article.asp?issn=2394-8108;year=2022;volume=8;issue=4;spage=172;epage=179;aulast=Eren;type=0